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Lookup NU author(s): Dr Gunther Ross,
Professor Robert Taylor,
Emeritus Professor Doug Turnbull,
Professor Robert Lightowlers
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Defects of the mitochondrial genome are a significant cause of disease. Patients suffer from a wide variety of clinical presentations, ranging from fatal infantile disease to mild muscle weakness. Most disorders, however, are characterized by inexorable progression: As mutations often cause defects in several components of the complexes that couple oxidative phosphorylation, this terminal state of oxidative metabolism cannot be readily bypassed by dietary means, leading to the search for novel therapies. In this article, we present the theory behind several concepts and report progress. We also discuss some of the recent difficulties encountered in the progress towards an antigenome approach to treating mtDNA disorders. (C) 2004 Elsevier B.V. All rights reserved.
Author(s): Smith PM, Ross GF, Taylor RW, Turnbull DM, Lightowlers RN
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Biochimica et Biophysica Acta: Bioenergetics. 6th European Meeting on Mitochondrial Pathology (Euromit 6)
Year of Conference: 2004
Publisher: Elsevier BV
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