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Lookup NU author(s): Dr Marie Smith,
Dr Michael Ward,
Dr Stephen Sturgiss,
Emeritus Professor John Davison
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Background. Animal work indicates that ovarian hormones are important in initiating and maintaining enhanced renal function in pregnant rats and that a renal response resembling pregnancy can be provoked in male rats exposed to pregnancy hormones. Women becoming pregnant following renal transplantation provide an opportunity to compare the functional response of male and female allografts to the gestational endocrine environment. Methods. This retrospective observational study included 20 renal allograft recipients (age 29.7 +/- 2.4 yrs) (mean +/- SE) who had 22 pregnancies beyond 24 weeks (gestation at delivery 35.5 +/- 0.6 weeks). Donor characteristics, transplant details, renal follow-up data, and information about pregnancy and allograft function were obtained from hospital notes. Results. Thirteen women received male allografts (donor age 30.0 +/- 3.9 years) (mean +/- SEM) and 7 women, female allografts (donor age 45.1 +/- 6.0 years) (P = .04). There were no significant differences between the two groups in maternal recipient age, transplant to pregnancy interval, antenatal complications, pregnancy outcome, or postnatal graft function. Compared to prepregnancy values serum creatinine (SCr) decrements and augmented 24-hour creatinine clearance (CrCl) were observed over the first trimester in both male and female allografts: DeltaCrCl from 106.8 +/- 13.2 mL/min to 114.4 +/- 11.4 mL/min (35.6% increase) and 71.8 +/- 7.4 to 89.5 +/- 11.3 mL/min (24.7% increase), respectively, and DeltaSCr from 90.1 +/- 5.4 mumol/L to 73.6 +/- 6.6 mumol/L (17.8% decrease) and 99.8 +/- 9.7 mumol/L to 78.0 +/- 5.7 mumol/L (13.5% decrease), respectively. Differences between the two groups did not reach statistical significance. Conclusions. Donor gender and/or age do not appear to influence the gestational renal response in kidney transplant recipients.
Author(s): Smith MC, Ward MK, Sturgiss SN, Milne JE, Davison JM
Publication type: Article
Publication status: Published
Journal: Transplantation Proceedings
ISSN (print): 0041-1345
ISSN (electronic): 1873-2623
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