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Absence of cholinergic deficits in "pure" vascular dementia

Lookup NU author(s): Emeritus Professor Elaine Perry, Dr Iryna Ziabreva, Emeritus Professor Robert Perry, Dr Dag Aarsland, Dr Clive Ballard


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Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases ( 9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.

Publication metadata

Author(s): Perry E, Ziabreva I, Perry R, Aarsland D, Ballard C

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2005

Volume: 64

Issue: 1

Pages: 132-133

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: AAN Enterprises, Inc