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Compromised arterial oxygen saturation in elderly asthma sufferers results in selective cognitive impairment

Lookup NU author(s): Mark Franks

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Abstract

Forty elderly patients with asthma or chronic obstructive pulmonary disorder (COPD) were compared to a comparison group of forty age-matched healthy volunteers on a range of measures of cognitive performance, and levels of arterial haemoglobin oxygen saturation recorded. Members of the patient group were found to have significantly lower oxygen saturation compared to the comparison group, and performed significantly poorer on tests of delayed word recall and serial subtractions, but not on other tasks. Correlational analysis between participants' oxygen saturation levels and test scores across the whole sample indicated significant positive relationships existed for the digit symbol substitution and serial subtractions tasks. The results are discussed in terms of cerebral oxygen delivery, glucose metabolism, age related cognitive decline, and relative task demands.

Publication metadata

Author(s): Moss M, Franks M, Briggs P, Kennedy D, Scholey A

Publication type: Article

Publication status: Published

Journal: Journal of Clinical and Experimental Neuropsychology

Year: 2005

Volume: 27

Issue: 2

Pages: 139-150

Print publication date: 01/02/2005

Online publication date: 16/02/2007

ISSN (print): 1380-3395

ISSN (electronic): 1744-411X

Publisher: Psychology Press

URL: http://dx.doi.org/10.1080/13803390490515450

DOI: 10.1080/13803390490515450

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