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The K variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients

Lookup NU author(s): Dr Clive Ballard, Dr Christopher Morris, Professor Raj KalariaORCiD, Professor Ian McKeith, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry


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Accumulating evidence suggests that butyrylcholinesterase (BuChE) plays an important role in the progression of cognitive deficits and Alzheimer-type pathology in dementia patients. We examined the relationship between the K variant of BuChE and the severity of deposits of amyloid (Aβ(1-42)) and phosphorylated tau in the temporal cortex (BA36) of 30 prospectively studied autopsy-diagnosed dementia ( Alzheimer's disease and dementia with Lewy bodies) patients. There was 42% less phosphorylated tau in BA36 in cases with ≥ 1 K compared with those with wild-type BuChE alleles (t = 2.2, p = 0.039), but no difference in the extent of Aβ(1-42) deposition. BuChE may play this role in the phosphorylation of tau, relevant to therapeutic inhibition of the enzyme. Copyright (C) 2005 S. Karger AG, Basel.

Publication metadata

Author(s): Ballard C, Morris C, Kalaria R, McKeith I, Perry R, Perry E

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2005

Volume: 19

Issue: 5-6

Pages: 357-360

Print publication date: 01/01/2005

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG


DOI: 10.1159/000084705


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