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Treatment of stiff person syndrome with rituximab

Lookup NU author(s): Professor Mark BakerORCiD, Professor John IsaacsORCiD, Dr Peter Fawcett, Emeritus Professor David Bates


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This case report is about the novel use of the anti-CD20 antibody, rituximab, in the treatment of a 41 year old woman with stiff person syndrome. She was admitted to hospital as an emergency with prolonged and painful extensor spasms affecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglobulin and cytotoxics. Treatment with rituximab induced a lasting clinical remission.

Publication metadata

Author(s): Baker MR, Das M, Isaacs J, Fawcett PRW, Bates D

Publication type: Article

Publication status: Published

Journal: Journal of Neurology, Neurosurgery and Psychiatry

Year: 2005

Volume: 76

Issue: 7

Pages: 999-1001

ISSN (print): 0022-3050

ISSN (electronic): 1468-330X

Publisher: BMJ Group

DOI: 10.1136/jnnp.2004.051144


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