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The H1c haplotype at the MAPT locus is associated with Alzheimer's disease

Lookup NU author(s): Dr Andrea Myers, Dr Christopher Morris

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Abstract

Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.

Publication metadata

Author(s): Myers AJ, Kaleem M, Marlowe L, Pittman AM, Lees AJ, Fung HC, Duckworth J, Leung D, Gibson A, Morris CM, de Silva R, Hardy J

Publication type: Article

Publication status: Published

Journal: Human Molecular Genetics

Year: 2005

Volume: 14

Issue: 16

Pages: 2399-2404

ISSN (print): 0964-6906

ISSN (electronic): 1460-2083

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/hmg/ddi241

DOI: 10.1093/hmg/ddi241

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