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Lookup NU author(s): Wolfgang Issing
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Large-scale genomic studies in cohorts have been made possible for the last few years thanks to the progress of molecular biology and bioinformatics. This systematic approach allows a better understanding of the molecular mechanisms of disease development and as a consequence can contribute to the rational design of new diagnostic and therapeutic tools. We present here the exhaustive genotyping of a candidate gene, tumor necrosis factor receptor I (TNFR1), in the genetic of resistance to immunodeficiency virus (GRIV) AIDS cohort. This gene was chosen because it is likely to be involved in the apoptosis pathways of CD4(+) and CD8(+) T-cells during human immunodeficiency virus I (HIV-1) infection. Seven frequent polymorphisms were characterized in 319 HIV-1 seropositive patients from the GRIV cohort with extreme disease progression phenotypes, slow progression or rapid progression, and in 427 healthy controls. The TNFRI gene locus does not appear to be part of any haploblock and contains only a small haploblock of two successive SNPs. One promoter SNP (TNFR1_17444594, position -581) and one intronic SNP (TNFR1_27223241, position +11511) gave weak positive signals of association (resp. P = 0.03 and P = 0.04) as well as two haplotypes. To our knowledge, this is the first genetic association study dealing with the TNFRI gene in AIDS and the putative associations identified will need to be validated through other AIDS cohort analyses or by further biological experimentation. (c) 2005 Elsevier SAS. All rights reserved.
Author(s): Diop G, Spadoni JL, Do H, Hirtzig T, Coulonges C, Labib T, Issing W, Rappaport J, Therwath A, Lathrop M, Matsuda F, Zagury JF
Publication type: Article
Publication status: Published
Journal: Biomedicine & Pharmacotherapy
Year: 2005
Volume: 59
Issue: 8
Pages: 474-480
ISSN (print): 0753-3322
ISSN (electronic): 1950-6007
Publisher: Elsevier Masson
URL: http://dx.doi.org/10.1016/j.biopha.2005.07.011
DOI: 10.1016/j.biopha.2005.07.011
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