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Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells

Lookup NU author(s): Professor Simon BaileyORCiD

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Abstract

This is the first report to comprehensively characterize the E2A-HLF fusion generated from the t(17;19)(q22;p13) translocation in childhood B-lineage acute lymphoblastic leukemia. E2A gene rearrangement and E2A-HLF transcript and protein expression were determined using conventional cytogenetics, fluorescent in situ hybridization, reverse transcriptase polymerase chain reaction and Western blotting in leukemic cells from three patients.

Publication metadata

Author(s): Yeung, J., Kempski, H., Neat, M., Bailey, S., Smith, O., Brady, H. J. M.

Publication type: Letter

Publication status: Published

Journal: Haematologica

Year: 2006

Volume: 91

Issue: 3

Pages: 422-424

ISSN (print): 0390-6078

ISSN (electronic): 1592-8721

URL: http://www.haematologica.org/cgi/content/abstract/91/3/422

PubMed id: 16531271

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