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Interstitial lung disease: progress and problems

Lookup NU author(s): Dr Stephen Bourke


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Interstitial lung disease involves all areas of medicine as it often occurs in patients with comorbidities or as a consequence of systemic diseases and their treatment. Typically the physician is faced with a breathless patient, a diffusely abnormal chest radiograph, and a wide differential diagnosis. Progress has been made in using high resolution computed tomography as the key investigation in characterising the pattern and extent of the disease. Bronchoalveolar lavage is particularly important in excluding infection as a cause of diffuse lung infiltrates. Surgical lung biopsies have led to a new classification system for the range of histopathological patterns of disease that were previously known by the collective term cryptogenic fibrosing alveolitis. Problems persist in deciding when a surgical lung biopsy is clinically justified, in understanding the pathogenesis of these diseases, and in finding more effective treatments.

Publication metadata

Author(s): Bourke SJ

Publication type: Review

Publication status: Published

Journal: Postgraduate Medical Journal

Year: 2006

Volume: 82

Issue: 970

Pages: 494-499

ISSN (print): 0032-5473

ISSN (electronic): 1469-0756


DOI: 10.1136/pgmj.2006.046417