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Lookup NU author(s): Professor Melissa BatesonORCiD
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Introduction Drugs that increase dopamine (DA) transmission have been shown to produce an overestimation of time in duration production procedures as exhibited by horizontal leftward shifts of the psychophysical functions. However, the generality of these results has been inconsistent in the literature. Materials and methods The present report evaluates the effects of five doses of methamphetamine (MAP) (0.5-1.5 mg/kg, i/p.) on two duration production procedures, the single duration peak-interval (PI) procedure and the multi-duration tri-peak procedure in rats. Results We replicated and extended prior results by showing a dose- dependent proportional overestimation of time that was equivalent on both procedures (i.e., subjects behaved as though they expected reinforcement to be available earlier in real time). Single-trials analyses demonstrated that the reduction in peak rate that is often observed after MAP administration is due to an increase in the proportion of trials in which responding occurred at very low rates and without temporal control. However, these low-rate trials were not the source of the leftward shift in the temporal estimates. Rather, we found that the leftward shift of the PI functions was due to proportional changes in the placement of temporally controlled high-rate responding, which is consistent with a DA-mediated alteration in clock speed.
Author(s): Matell MS, Bateson M, Meck WH
Publication type: Article
Publication status: Published
Journal: Psychopharmacology
Year: 2006
Volume: 188
Issue: 2
Pages: 201-212
ISSN (print): 0033-3158
ISSN (electronic): 1432-2072
Publisher: Springer
URL: http://dx.doi.org/10.1007/s00213-006-0489-x
DOI: 10.1007/s00213-006-0489-x
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