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Agonal period in potential non-heart-beating donors

Lookup NU author(s): John Asher, Colin Wilson, Aliu Sanni, Hugh Wyrley-Birch, David Rix, Professor Derek Manas, David Talbot


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The shortage of donor kidneys for renal transplantation is becoming more severe as the gap between the number of patients waiting for renal transplantation and the number of cadaveric organs available continues to widen. Therefore, many centres have started using non-heart-beating (NHB) donors. There was no clear plan for maximal duration of agonal period in Maastricht category NHB donors after withdrawal of treatment in Newcastle. This withdrawal has been audited in retrospect. Our current wait time is now a maximum of 5 hours; however, previously there have been some considerably longer periods. Concern has always been expressed about poor quality with protracted periods. Nonuse in this review of 58 kidneys can be expressed against time: 0 to 2 hours 13%, 2 to 5 hours 33%, and > 5 hours 45%. Therefore, though the nonuse rate was significantly different between 0 to 2 hours and > 5 hours (P <.05, chi-square), there were 16 transplants performed with kidneys > 2 hours and 12 transplanted > 5 hours. In conclusion, although good usable kidneys can still be used with protracted withdrawal, there are considerable logistical difficulties with our 5-hour cut-off, which means that one third of potential kidneys will not be utilized.

Publication metadata

Author(s): Sohrabi S, Navarro A, Asher J, Wilson C, Sanni A, Wyrley-Birch H, Arland V, Reddy M, Rix D, Jacques B, Manas D, Talbot D

Publication type: Article

Publication status: Published

Journal: Transplantation Proceedings

Year: 2006

Volume: 38

Issue: 8

Pages: 2629-2630

ISSN (print): 0041-1345

ISSN (electronic): 1873-2623

Publisher: Elsevier Inc.


DOI: 10.1016/j.transproceed.2006.08.005


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