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Multiple virus isolations in children with acute lymphoblastic-leukemia

Lookup NU author(s): Dr Michael Reid, Emeritus Professor Alan Craft, Dr Jennifer Kernahan


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Seventy-two children receiving treatment for acute lymphoblastic leukaemia (ALL) and 796 control children were surveyed virologically.

In 20 of the 99 infective episodes (20 per cent), concurrent multiple virus isolations occurred. Dual isolations occurred twice in two children and in one child three viruses were present simultaneously. This rate of multiple virus isolation is significantly greater than that observed (2ยท5 per cent) in the control children. Only five episodes of multiple virus isolation in the children with ALL were not associated with serious illness. There was not a close relationship between lymphopenia and the presence of multiple virus isolation. The recognition of this phenomenon is one step towards a better understanding of the nature of virus infections in children with ALL.

Publication metadata

Author(s): Bruce, E., Reid, M. M., Craft, A. W., Kernahan, J., Gardner, P. S.

Publication type: Article

Publication status: Published

Journal: Journal of Infection

Year: 1979

Volume: 1

Issue: 3

Pages: 243-248

Print publication date: 01/09/1979

ISSN (print): 0163-4453

ISSN (electronic): 1532-2742


DOI: 10.1016/S0163-4453(79)91263-5


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