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Aminoglycoside-associated hypomagnesaemia in children with cystic fibrosis

Lookup NU author(s): Dr David Spencer

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Abstract

Hypomagnesaemia in children with cystic fibrosis (CF) is under-recognized. We report a child with CF who developed significant hypomagnesaemia following intravenous (i.v.) treatment with aminoglycosides for exacerbations of Pseudomonas aeruginosa infection. Three additional cases have also been observed. Investigations in two patients have revealed excessive renal loss of magnesium. It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia, and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides.

Publication metadata

Author(s): Akbar A, Rees JHM, Nyamugunduru G, English MW, Spencer DA, Weller PH

Publication type: Article

Publication status: Published

Journal: Acta Paediatrica

Year: 1999

Volume: 88

Issue: 7

Pages: 783-785

Print publication date: 01/07/1999

ISSN (print): 0803-5253

ISSN (electronic): 1651-2227

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1651-2227.1999.tb00044.x

DOI: 10.1111/j.1651-2227.1999.tb00044.x

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