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Vitamin D binding protein gene in male osteoporosis: Association of plasma DBP and bone mineral density with (TAAA)(n)-Alu polymorphism in DBP

Lookup NU author(s): Dr Surinder Papiha, Emeritus Professor Roger Francis, Dr Harish Datta


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Vitamin D binding protein (DBP) is a major carrier protein for the vitamin D metabolites, but may also play an important role in osteoclast differentiation. Polymorphisms of the DBP gene have been reported, including (TAAA)(n)-Alu repeat polymorphisms downstream of intron 8. We have examined the relationship between polymorphisms of the DBP gene and bone mineral density (BMD) and vertebral fractures in a group of 26 men with vertebral fractures but no underlying secondary cause of osteoporosis (median age 64, ages 27-72 years) and 21 male control subjects (median age 65, ages 40-77 years). There was no apparent effect of DBP phenotype on BMD, but there was a relationship between certain genotypes of (TAAA)(n)-Alu repeats and reduced BMD and vertebral fracture. Lumbar spine and femoral neck BMD were significantly lower in men with 10/8 genotype than 10/10 genotype (P < 0.05). Furthermore, the predominant genotype in men with vertebral fractures was 10/8, whereas the most common genotype in control subjects was 10/10 (odds ratio 56; 95% confidence interval 7-445). Plasma DBP was higher in men with 10/8 genotype than those with 10/10 genotype (P < 0.05), and patients with vertebral fractures were found to have higher levels than control subjects (P < 0.0005). Although our study is small because of the relative rarity of idiopathic osteoporosis in men, the results suggest that (TAAA)(n)-Alu polymorphism may have an important effect on plasma levels of DBP, bone density and fracture risk in men.

Publication metadata

Author(s): Francis RM; Datta HK; Papiha SS; Allcroft LC; Kanan RM

Publication type: Article

Publication status: Published

Journal: Calcified Tissue International

Year: 1999

Volume: 65

Issue: 4

Pages: 262-266

ISSN (print): 0171-967X

ISSN (electronic): 1432-0827

Publisher: Springer


DOI: 10.1007/s002239900695


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