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A randomized comparison of narrow-band TL-01 phototherapy and PUVA photochemotherapy for psoriasis

Lookup NU author(s): Emeritus Professor Brian Diffey, Professor Peter Farr


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Background: Although PUVA treatment of psoriasis is more effective than conventional or broad-band UVB phototherapy two Small studies have suggested that narrow-band or TL-01 phototherapy may have a therapeutic effect equal to PUVA. If confirmed, this would be of considerable importance as TL-01 therapy is likely to be considerably safer in the long term than PUVA. Objective: The purpose of this study was to compare PUVA with narrow-band (TL-01) phototherapy in psoriasis. Methods: We studied 100 patients with plaque-type psoriasis who were randomly allocated to twice-weekly treatment with PUVA Or narrow-band UVB. Results: Clearance of psoriasis was achieved in a significantly greater proportion of patients treated with PUVA (84%) than with TL-01 (63%) (P = .018), and with significantly fewer treatments (median number of treatments for clearance with PCNA, 16.7; with TL-01, 25.3; P = .001). Only 12% of those treated with TL-01 were clear of psoriasis 6 months after finishing treatment compared with 35% for PUVA (P = .002). Conclusion: When given twice weekly, PUVA is more effective for psoriasis than narrow-band UVB phototherapy.

Publication metadata

Author(s): Gordon PM, Diffey BL, Matthews JNS, Farr PM

Publication type: Article

Publication status: Published

Journal: Journal of the American Academy of Dermatology

Year: 1999

Volume: 41

Issue: 5

Pages: 728-732

Print publication date: 01/11/1999

ISSN (print): 0190-9622

ISSN (electronic): 1097-6787

Publisher: Mosby, Inc.


DOI: 10.1016/S0190-9622(99)70008-3


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