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Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03

Lookup NU author(s): Dr David Neill, Professor Jim Edwardson, Professor Ian McKeith, Dr Clive Ballard, Dr Christopher Morris, Dr Evelyn Jaros, Emeritus Professor Robert Perry


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The allele frequency of the HLA-DRB1gene was compared between groups of 48 clinically diagnosed elderly Alzheimer's disease (AD) cases and 44 pathologically confirmed elderly control cases. Specific primers were used to PCR amplify the highly polymorphic second exon of HLA-DRB1 using DNA extracted from blood samples or frozen brain tissue. The allele type was identified using sequence specific oligonucleotide probes. The results showed an increased frequency of DRB1*03 (P < 0.006) and decreased frequency of DRB1*09 (P < 0.049) in the AD cases compared with the controls. The results suggest that DRB1*03 is associated with an increased risk and DRB1*09 a possible decreased risk for the development of late-onset AD with first detectable clinical symptoms occurring at age 75 years or greater.

Publication metadata

Author(s): Mckeith I; Edwardson JA; Perry R; Morris C; Ballard C; Jaros E; Neill D; Curran MD; Middleton D; Mawhinney H; Ince P

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 1999

Volume: 275

Issue: 2

Pages: 137-140

Print publication date: 01/11/1999

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier


DOI: 10.1016/S0304-3940(99)00761-2


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