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Sea-NineTM 211(4,5-dichloro-2-(n-octyl)-3(2H)-isothiazolone) is a potent stimulator of eicosanoid biosynthesis in the sea squirt, Ciona intestinalis (L.)

Lookup NU author(s): Professor Tony Clare


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The isothiazolone, Sea-Nine 211(TM), is a broad-spectrum antifoulant whose mechanism of action is poorly understood. In the light of recent reports that eicosanoids may modulate invertebrate larval settlement, the present study examined the effect of Sea-Nine 211 on eicosanoid biosynthesis in the sea squirt, Ciona intestinalis. Using RP-HPLC and examination of peak absorption spectra, the tunic of this species was shown to produce a range of lipoxygenase products, including 8-HEPE, 12-HEPE, 8,15-diHEPE and 8,15-diHETE. Sea-Nine 211(TM) was similar in potency to the calcium ionophore, A 23187, in inducing biosynthesis of these eicosanoids, being maximally effective at 5-10 mu M. While the effect of Sea-Nine 211 on C. intestinalis settlement has yet to be examined, it is suggested that this antifoulant may exert its action, at least in part, by modulating eicosanoid biosynthesis.

Publication metadata

Author(s): Knight J, Rowley AF, Clare AS

Publication type: Article

Publication status: Published

Journal: Biofouling

Year: 1999

Volume: 14

Issue: 3

Pages: 213-217

Print publication date: 01/12/1999

ISSN (print): 0892-7014

ISSN (electronic): 1026-7867

Publisher: Taylor & Francis Ltd.


DOI: 10.1080/08927019909378412


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