Toggle Main Menu Toggle Search

Open Access padlockePrints

The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

Lookup NU author(s): Professor Ian McKeith, Dr Christopher Morris


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

Publication metadata

Author(s): McKeith IG; Morris CM; Xu WM; Liu LZ; Emson P; Harrington CR; Perry RH; Charles IG

Publication type: Article

Publication status: Published

Journal: Neuroreport

Year: 2000

Volume: 11

Issue: 2

Pages: 297-299

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00001756-200002070-00015


Altmetrics provided by Altmetric