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A retrospective study of outcome of Mohs' micrographic surgery for cutaneous squamous cell carcinoma using formalin fixed sections

Lookup NU author(s): Dr Niamh Leonard, Professor Archibald Malcolm, Dr Clifford Lawrence, Dr Michael Dahl


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The surgical management of recurrent or large squamous cell carcinoma (SCC) can be challenging as tumours often extend beyond visible margins. Micrographic surgery is a potentially effective method of ensuring complete clearance of tumour. A retrospective study of all cases of SCC treated by micrographic surgery in this department between 1986 and 1996 has been done. Sixty-one patients were treated using a formalin-fixed paraffin-embedded tissue technique with a median follow-up of 4 years, In two cases there was local recurrence and in three others metastasis to local Lymph nodes. The overall cure rate was 92% (56 of 61), which compares favourably with published series using chemosurgery and frozen tissue techniques. The results show that this technique of micrographic surgery is a satisfactory and cost-effective alternative to conventional frozen section techniques in the treatment of SCC. The formalin-fixed tissue method has the advantage of providing high-quality permanent histological sections using existing conventional pathology services.

Publication metadata

Author(s): Turner RJ, Leonard N, Malcolm AJ, Lawrence CM, Dahl MGC

Publication type: Article

Publication status: Published

Journal: British Journal of Dermatology

Year: 2000

Volume: 142

Issue: 4

Pages: 752-757

ISSN (print): 0007-0963

ISSN (electronic): 1365-2133

Publisher: Wiley-Blackwell


DOI: 10.1046/j.1365-2133.2000.03422.x


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