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Differences in genotypes of Helicobacter pylori from different human populations

Lookup NU author(s): Dr Julian Thomas

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Abstract

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric pathogen. Five types of deletion, insertion, and substitution motifs were found at the right end of the H. pylori cag pathogenicity island. Of the three most common motifs, type I predominated in Spaniards, native Peruvians, and Guatemalan Ladinos (mixed Amerindian-European ancestry) and also in native Africans and U.S. residents; type II predominated among Japanese and Chinese; and type III predominated in Indians from Calcutta. Sequences in the cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native Peruvians were also more like those from Spaniards than those from Asians. These indications of relatedness of Latin American and Spanish strains, despite the closer genetic relatedness of Amerindian and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about. 500 years ago. This thinking, in turn, suggests that H. pylori infection might have become widespread in people quite recently in human evolution.

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Author(s): Thomas JE; Kersulyte D; Mukhopadhyay AK; Velapatino B; Su WW; Pan ZJ; Garcia C; Hernandez V; Valdez Y; Mistry RS; Gilman RH; Yuan Y; Gao H; Alarcon T; Lopez-Brea M; Nair GB; Chowdhury A; Datta S; Shirai M; Nakazawa T; Ally R; Segal I; Wong BCY; Lam SK; Olfat FO; Boren T; Engstrand L; Torres O; Schneider R; Czinn S; Berg DE

Publication type: Article

Publication status: Published

Journal: Journal of Bacteriology

Year: 2000

Volume: 182

Issue: 11

Pages: 3210-3218

ISSN (print): 0021-9193

ISSN (electronic): 1098-5530

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/JB.182.11.3210-3218.2000

DOI: 10.1128/JB.182.11.3210-3218.2000

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