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The future of somatostatin analogue therapy

Lookup NU author(s): Dr Robert James


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Since its discovery almost 30 years ago, the mode of action and therapeutic applications of somatostatin have been defined. In particular the cloning and characterization of somatostatin receptor subtypes has facilitated the development of high affinity analogues. In the context of pituitary disease, long-acting somatostatin analogues (octreotide, lanreotide) have been used to treat a variety of pituitary tumours but are most efficacious for the treatment of GH and TSH-secreting adenomas. In patients with acromegaly, depot preparations of these analogues are administered intramuscularly every 10-28 days and provide consistent suppression of GH levels to <5 mU/l in approximately 50-65% of all cases. Even more specific somatostatin receptor analogues are under development. Finally, radiolabelled somatostatin analogue scintigraphy and, in larger doses, therapy, are now established tools in the evaluation and treatment of neuroendocrine tumours.

Publication metadata

Author(s): James RA; Stewart PM

Publication type: Article

Publication status: Published

Journal: Best Practice & Research: Clinical Endocrinology & Metabolism

Year: 1999

Volume: 13

Issue: 3

Pages: 409-418

Print publication date: 01/10/1999

ISSN (print):

ISSN (electronic): 1878-1594

Publisher: Bailliere Tindall


DOI: 10.1053/beem.1999.0031


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