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Lookup NU author(s): Emeritus Professor Drew Rowan,
Emeritus Professor Tim Cawston
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Oncostatin M in combination with interleukin-l (IL-1) induced a rapid and reproducible release of collagen from bovine nasal cartilage in culture. This release was accompanied by a high collagenolytic activity and low or absent tissue inhibitor of metalloproteinase-1 activity in the culture medium. Transforming growth factor-beta 1 was able to block this release of collagen from the tissue, and reduce the expression and secretion of collagenases whilst maintaining TIMP-1 levels from bovine nasal chondrocytes, This study shows for the first time that TGF-beta 1 can protect cartilage collagen from destruction. (C) 2000 Academic Press.
Author(s): Hui W, Rowan AD, Cawston TE
Publication type: Article
Publication status: Published
ISSN (print): 1043-4666
ISSN (electronic): 1096-0023
Publisher: Academic Press
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