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Transforming growth factor-beta 1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with IL-1 alpha

Lookup NU author(s): Emeritus Professor Drew Rowan, Emeritus Professor Tim Cawston


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Oncostatin M in combination with interleukin-l (IL-1) induced a rapid and reproducible release of collagen from bovine nasal cartilage in culture. This release was accompanied by a high collagenolytic activity and low or absent tissue inhibitor of metalloproteinase-1 activity in the culture medium. Transforming growth factor-beta 1 was able to block this release of collagen from the tissue, and reduce the expression and secretion of collagenases whilst maintaining TIMP-1 levels from bovine nasal chondrocytes, This study shows for the first time that TGF-beta 1 can protect cartilage collagen from destruction. (C) 2000 Academic Press.

Publication metadata

Author(s): Hui W, Rowan AD, Cawston TE

Publication type: Article

Publication status: Published

Journal: Cytokine

Year: 2000

Volume: 12

Issue: 6

Pages: 765-769

ISSN (print): 1043-4666

ISSN (electronic): 1096-0023

Publisher: Academic Press


DOI: 10.1006/cyto.1999.0625


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