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Distribution of amyloid beta(42) in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease

Lookup NU author(s): Professor Alan ThomasORCiD, Dr Christopher Morris, Emeritus Professor Nicol Ferrier, Professor Raj KalariaORCiD


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Amyloid beta (AP) deposits and neurofibrillary pathology are characteristic features of Alzheimer's disease (AD), The association of A beta with cerebral vessels is an intriguing feature of AD. While some degree of cerebral A beta angiopathy involving the Leptomeninges and intraparenchymal vessels occurs in almost all cases of AD, the proportion of microvessels within a neocortical region containing deposits of A beta peptide is not known, In this study, we examined a cohort of clinically and pathologically evaluated AD cases to assess the percentage of cerebral microvessels in the temporal cortex and parahippocampal gyrus associated with the predominant, A beta(42) form of the peptide, We also assessed whether the distribution and burden of amyloid was related to apolipoprotein E (APOE) genotype, Using double immunostaining methods, we surprisingly found that at least 40% of the microvessels in the two brain regions contained A beta(42) deposits. There was no correlation of such localization with APOE genotype, however, epsilon 4 homozygotes revealed a greater burden of A beta(40). These observations suggest that high proportions of cortical microvessels are associated with A beta(42), which may affect microvascular function.

Publication metadata

Author(s): Kalaria RN; Morris CM; Ferrier IN; Thomas AJ

Publication type: Article

Publication status: Published

Journal: Annals of the New York Academy of Science

Year: 2000

Volume: 903

Pages: 83-88

ISSN (print): 0077-8923

ISSN (electronic): 1749-6632

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1749-6632.2000.tb06353.x


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