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Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension

Lookup NU author(s): Dr David Mantle, Dr Saeed Ahmed


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The objective of this investigation was to compare changes in antioxidant status (together with other metabolites relevant to hypertension) in plasma and cardiac tissue from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), following 8 weeks of treatment with lisinopril (angiotensin converting enzyme inhibitor) or amlodipine (Ca2+ channel antagonist) respectively. There was no significant difference in the levels of total antioxidant capacity, retinol, urea, albumin or triglyceride in plasma from SHR or WKY rats, with or without lisinopril or amlodipine treatment. However in SHR rats, levels of alpha-tocopherol were substantially reduced in both plasma (-54% WKY, P < 0.01) and cardiac tissue (-43% WKY, P < 0.05). Treatment with lisinopril ameliorated reduced levels of plasma alpha-tocopherol in SHR rats, but not in cardiac tissue. Amlodipine treatment had no effect on alpha-tocopherol levels in plasma or cardiac tissue in SHR rats. in SHR rats total cholesterol levels were significantly lower than WKY controls (-36%, P < 0.001). This effect was reversed in lisinopril treated SHR rats (+27%, P < 0.01). Plasma high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol were reduced in untreated SHR rats (P < 0.025) when compared to WKY controls, neither lisinopril nor amlodipine treatment significantly altered these parameters. These findings suggest possible alternative mechanisms of action for lisinopril, and reinforce its use in hypertensive patients or patients with left ventricular hypertrophy. (C) 2000 Elsevier Science B.V. All rights reserved.

Publication metadata

Author(s): Mantle D, Patel VB, Why HJF, Ahmed S, Rahman I, MacNee W, Wassif WS, Richardson PJ, Preedy VR

Publication type: Article

Publication status: Published

Journal: Clinica Chimica Acta

Year: 2000

Volume: 299

Issue: 1-2

Pages: 1-10

ISSN (print): 0009-8981

ISSN (electronic): 1873-3492

Publisher: Elsevier B.V.


DOI: 10.1016/S0009-8981(00)00270-9


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