Browse by author
Lookup NU author(s): Dr David Mantle,
Dr Saeed Ahmed
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The objective of this investigation was to compare changes in antioxidant status (together with other metabolites relevant to hypertension) in plasma and cardiac tissue from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), following 8 weeks of treatment with lisinopril (angiotensin converting enzyme inhibitor) or amlodipine (Ca2+ channel antagonist) respectively. There was no significant difference in the levels of total antioxidant capacity, retinol, urea, albumin or triglyceride in plasma from SHR or WKY rats, with or without lisinopril or amlodipine treatment. However in SHR rats, levels of alpha-tocopherol were substantially reduced in both plasma (-54% WKY, P < 0.01) and cardiac tissue (-43% WKY, P < 0.05). Treatment with lisinopril ameliorated reduced levels of plasma alpha-tocopherol in SHR rats, but not in cardiac tissue. Amlodipine treatment had no effect on alpha-tocopherol levels in plasma or cardiac tissue in SHR rats. in SHR rats total cholesterol levels were significantly lower than WKY controls (-36%, P < 0.001). This effect was reversed in lisinopril treated SHR rats (+27%, P < 0.01). Plasma high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol were reduced in untreated SHR rats (P < 0.025) when compared to WKY controls, neither lisinopril nor amlodipine treatment significantly altered these parameters. These findings suggest possible alternative mechanisms of action for lisinopril, and reinforce its use in hypertensive patients or patients with left ventricular hypertrophy. (C) 2000 Elsevier Science B.V. All rights reserved.
Author(s): Mantle D, Patel VB, Why HJF, Ahmed S, Rahman I, MacNee W, Wassif WS, Richardson PJ, Preedy VR
Publication type: Article
Publication status: Published
Journal: Clinica Chimica Acta
ISSN (print): 0009-8981
ISSN (electronic): 1873-3492
Publisher: Elsevier B.V.
Altmetrics provided by Altmetric