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Lookup NU author(s): Dr David Walker
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To examine the genetic contribution of HLA and non-HLA genes in the etiopathogenesis of rheumatoid arthritis (RA), 60 Caucasian multiplex families were identified and DNA analyzed for over 52 markers including DRB1, DQA1 and DQB1 alleles. Many of the markers were chosen because of close proximity to candidate genes suggested by previous studies or models of pathogenesis. Sibling pair analysis (SIBPAL), relative pair analysis (RELPAL) and linkage studies using two different models of inheritance suggested linkage for the MHC and two additional chromosomal regions: chromosome 2 (D2S443 near CD8 and IG kappa; 2p13-2p11.1), and chromosome 15 (CYP19-estrogen synthase; 15q15). No support was found for two chromosomal regions, 1p36 and 3q13, recently suggested by other studies. We used transmission disequilibrium testing (TDT), conditional logistic regression, and segregation analysis to study the contributions that the shared epitope and TNF-e have in contributing to risk for RA. These studies provide additional evidence that the association of HLA alleles in RA patients from multiplex families is similar to that observed in sporadic disease, suggest candidate regions for further analysis and find additional support for an association of TNF-c alleles with RA susceptibility.
Author(s): Bali D, Gourley S, Kostyu DD, Goel N, Bruce I, Bell A, Walker DJ, Tran K, Zhu DK, Costello TJ, Amos CI, Seldin MF
Publication type: Article
Publication status: Published
Journal: Genes and Immunity
Year: 1999
Volume: 1
Issue: 1
Pages: 28-36
Print publication date: 01/09/1999
ISSN (print): 1466-4879
ISSN (electronic): 1476-5470
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1038/sj.gene.6363635
DOI: 10.1038/sj.gene.6363635
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