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Gastric emptying rate of solids is reduced in a group of ileostomy patients

Lookup NU author(s): Professor John Mathers


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Feedback inhibition from the colon acts as a potent inhibitor of gastrointestinal motility via an array of gut peptides and neural pathways. The effect of total colonectomy on gastric emptying was assessed in five healthy ileostomy patients (<5 cm ileal resection) and five matched controls. Each subject consumed two isoenergetic test meals of contrasting fat-carbohydrate ratio in random order. Emptying of solids was measured using the [C-13]octanoic acid breath test, and liquid emptying was assessed after oral dosing with paracetamol, Ileostomist subjects exhibited an increased half-emptying time for solids (P = 0.047), which included components of an increased gastric lag time (P = 0.004) and a reduction in the linear emptying rate (P = 0.003). There was no difference in the pattern of liquid emptying between subject groups. In conclusion, the gastric emptying rate of solids was reduced in ileostomy patients compared with controls.

Publication metadata

Author(s): Mathers JC; Robertson MD

Publication type: Article

Publication status: Published

Journal: Digestive Diseases and Sciences

Year: 2000

Volume: 45

Issue: 7

Pages: 1285-1292

ISSN (print): 0163-2116

ISSN (electronic): 1573-2568

Publisher: Springer New York LLC


DOI: 10.1023/A:1005587516233


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