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Lookup NU author(s): Professor John Mathers
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Feedback inhibition from the colon acts as a potent inhibitor of gastrointestinal motility via an array of gut peptides and neural pathways. The effect of total colonectomy on gastric emptying was assessed in five healthy ileostomy patients (<5 cm ileal resection) and five matched controls. Each subject consumed two isoenergetic test meals of contrasting fat-carbohydrate ratio in random order. Emptying of solids was measured using the [C-13]octanoic acid breath test, and liquid emptying was assessed after oral dosing with paracetamol, Ileostomist subjects exhibited an increased half-emptying time for solids (P = 0.047), which included components of an increased gastric lag time (P = 0.004) and a reduction in the linear emptying rate (P = 0.003). There was no difference in the pattern of liquid emptying between subject groups. In conclusion, the gastric emptying rate of solids was reduced in ileostomy patients compared with controls.
Author(s): Mathers JC; Robertson MD
Publication type: Article
Publication status: Published
Journal: Digestive Diseases and Sciences
ISSN (print): 0163-2116
ISSN (electronic): 1573-2568
Publisher: Springer New York LLC
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