Toggle Main Menu Toggle Search

Open Access padlockePrints

Urinary soluble IL-6 receptor levels after cardiopulmonary bypass

Lookup NU author(s): Professor David Deehan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

To investigate the possible role of soluble interleukin 6 receptor (sIL-6r) in the inflammatory response to cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC), we examined the levels of sIL-6r in the urine of 50 patients undergoing coronary artery bypass surgery. The presence of sIL-6r in urine was confirmed in these patients, with levels rising from 6 pg/ml preoperatively to 19.5 pg/ml at 6 h and 41 pg/ml at 24 h after the start of cardiopulmonary bypass. Cardiopulmonary bypass leads to a rise in sIL-6r in urine that has not returned to normal after 24 h, suggesting a role for sIL-6r acid IL-6 in the inflammatory response to such surgery. Determination of cytokine receptor presence in urine offers a non-invasive approach to the monitoring of the immune and inflammatory response to the stress of surgical and traumatic injury. (C) 2000 Academic Press.


Publication metadata

Author(s): Sutherland AG, Deehan DJ

Publication type: Note

Publication status: Published

Journal: Cytokine

Year: 2000

Volume: 12

Issue: 9

Pages: 1441-1443

ISSN (print): 1359-6101

ISSN (electronic): 1879-0305

URL: http://dx.doi.org/10.1006/cyto.2000.0738

DOI: 10.1006/cyto.2000.0738


Share