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Urinary soluble IL-6 receptor levels after cardiopulmonary bypass

Lookup NU author(s): Professor David Deehan


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To investigate the possible role of soluble interleukin 6 receptor (sIL-6r) in the inflammatory response to cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC), we examined the levels of sIL-6r in the urine of 50 patients undergoing coronary artery bypass surgery. The presence of sIL-6r in urine was confirmed in these patients, with levels rising from 6 pg/ml preoperatively to 19.5 pg/ml at 6 h and 41 pg/ml at 24 h after the start of cardiopulmonary bypass. Cardiopulmonary bypass leads to a rise in sIL-6r in urine that has not returned to normal after 24 h, suggesting a role for sIL-6r acid IL-6 in the inflammatory response to such surgery. Determination of cytokine receptor presence in urine offers a non-invasive approach to the monitoring of the immune and inflammatory response to the stress of surgical and traumatic injury. (C) 2000 Academic Press.

Publication metadata

Author(s): Sutherland AG, Deehan DJ

Publication type: Note

Publication status: Published

Journal: Cytokine

Year: 2000

Volume: 12

Issue: 9

Pages: 1441-1443

ISSN (print): 1359-6101

ISSN (electronic): 1879-0305


DOI: 10.1006/cyto.2000.0738