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Clinical course of patients with major histocompatibility complex class II deficiency

Lookup NU author(s): Professor Mushtaq Saleem, Professor Andrew Cant


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The clinical course of 10 children who have been diagnosed with major histocompatibility complex (MHC) class II deficiency (bare lymphocyte syndrome) in the UK over the past eight years is described. They have had a generally poor prognosis, with only two of the 10 still alive despite eight attempts at bone marrow transplantation in six patients. Overwhelming viral infection was the predominant cause of death. Alternative transplant strategies or novel therapies are required for these patients.

Publication metadata

Author(s): Saleem MA, Arkwright PD, Davies EG, Cant AJ, Veys PA

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2000

Volume: 83

Issue: 4

Pages: 356-359

ISSN (print): 0003-9888

ISSN (electronic):

Publisher: BMJ Publishing Group Ltd


DOI: 10.1136/adc.83.4.356

PubMed id: 10999878


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