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Study on synthesis of ethyl 3-oxo-(S)-(+)-6,7-di-O-isopropylidene-6,7-dihydroxyheptanoate

Lookup NU author(s): Emeritus Professor Bernard Golding


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As a key starting material in synthesis of HIV-RT inhibitors, Ethyl 3-oxo-(S)-(+)-6,7-di-O-isopropylidene-6,7-dihydroxyheptanoate (1) was synthesized from (S)-(+)-glutamic acid and Meldrum's acid (7) through six steps of reactions. The structures of all compounds were characterized by elemental analysis, IR, H-1 MMR, C-13 NMR and MS.

Publication metadata

Author(s): Liu JY, Ma XY, Golding BT

Publication type: Article

Publication status: Published

Journal: Chinese Journal of Inorganic Chemistry

Year: 2001

Volume: 21

Issue: 1

Pages: 71-74

ISSN (print): 0253-2786

ISSN (electronic):

Publisher: Kexue Chubanshe