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Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer

Lookup NU author(s): Emerita Professor Janet Wilson

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Abstract

The purpose of this study was to determine whether mucin expression is altered in laryngeal cancer. MUC1 and MUC2 mucin expression was examined in biopsy specimens from 80 patients that comprised 23 laryngeal dysplasias, 36 laryngeal carcinomas, and 21 normal larynx control specimens. High MUC1 expression was found in all 3 groups (P = 0.689, Fisher exact test). However, significantly higher levels of MUC2 expression were detected in carcinomas compared with dysplasias and control specimens (P = 0.009, Fisher exact test). Altered MUGS expression may be an important step in carcinogenesis in laryngeal cancer.


Publication metadata

Author(s): Jeannon, J.P., Stafford, F.W., Soames, J.V., Wilson, J.A.

Publication type: Article

Publication status: Unknown

Journal: Otolaryngology - Head and Neck Surgery

Year: 2001

Volume: 124

Issue: 2

Pages: 199-202

ISSN (print): 0194-5998

ISSN (electronic): 1097-6817

URL: http://dx.doi.org/10.1067/mhn.2001.112481

DOI: 10.1067/mhn.2001.112481


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