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Parkinson's disease is not associated with combined alpha-synuclein/apolipoprotein E susceptibility genotype

Lookup NU author(s): Dr Christopher Morris


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A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha -synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha -synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.

Publication metadata

Author(s): Khan N, Graham E, Dixon P, Morris C, Mander A, Clayton D, Vaughan J, Quinn N, Lees A, Daniel S, Wood N, de Silva R

Publication type: Article

Publication status: Published

Journal: Annals of Neurology

Year: 2001

Volume: 49

Issue: 5

Pages: 665-668

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/ana.1027


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