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Improved catalytic procedures for the copper(I)-promoted reactions of beta-amido zinc reagents

Lookup NU author(s): Christopher Hunter, Professor Richard Jackson


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Copper-catalysed cross coupling of the beta -aminoalkylzinc reagents 1a and 2 with unsaturated alkyl halides gives beta -unsaturated ethylamines in 47-78% yield (4 examples) and enantiomerically pure beta -unsaturated propylamines in 55-69% yield (3 examples). This method is more efficient for simple beta -aminoalkylzinc reagents than that using stoichiometric copper.

Publication metadata

Author(s): Hunter C, Jackson RFW, Rami HK

Publication type: Article

Publication status: Published

Journal: Journal of the Royal Chemical Society: Perkin Transactions 1

Year: 2001

Issue: 12

Pages: 1349-1352

ISSN (print): 1472-7781

ISSN (electronic): 1364-5463

Publisher: Royal Society of Chemistry


DOI: 10.1039/b102446a


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