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Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and crohn disease in multiple populations from northeast England

Lookup NU author(s): Dr Ann Curtis, Dr Mark Welfare, Dr Mark Hudson, Dr Peter Donaldson, Dr John Mansfield


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Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract of unknown aetiology, phenotypically categorized into ulcerative colitis (UC) and Crohn disease (CD). Genetic factors are of considerable importance in both. The genetic relationship between IBD and the interleukin-1 receptor antagonist and interleukin-1 beta genes (IL-IRN, and IL-1B, respectively) has been extensively studied. However, the quality and outcome of the genetic association studies, in particular the association with IL-1RN*2, have been variable and these associations remain controversial. The aim of the present study was to re-investigate these two candidate genes in a large series of IBD patients from a genetically homogeneous population with low levels of population admixture, and provide a definitive answer to this question. Methods: A total of 529 northern European Caucasoid patients with IBD (347 UC. 182 CD) and 289 racially and geographically matched healthy controls were studied. The IL-IRN and IL-IB genotypes, allele frequencies and most probable haplotypes were determined by standard PCR protocols. Results: There were no significant differences in the distributions of the IL-IRN and IL-IB genotypes, allele frequencies or haplotypes in either patient series compared to healthy controls or between clinical subsets. Genotype distribution and frequency data for allele 2 (IL-1RN*2) in particular showed no significant differences across all patient groups for all three series. Conclusion: The findings of this study lead us to reject the IL-IRN*2 association with IBD.

Publication metadata

Author(s): Craggs A, West S, Curtis A, Welfare MR, Hudson M, Donaldson PT, Mansfield JC

Publication type: Article

Publication status: Published

Journal: Scandinavian Journal of Gastroenterology

Year: 2001

Volume: 36

Issue: 11

Pages: 1173-1178

ISSN (print): 0036-5521

ISSN (electronic): 1502-7708

Publisher: Informa Healthcare


DOI: 10.1080/00365520152584806


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