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Lookup NU author(s): Martin Stockley,
Emeritus Professor Bill CleggORCiD,
Professor Bernard Golding,
Dr Laurent Rigoreau,
Professor Roger Griffin
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The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035) is described. The structure of OK-1035 was validated by X-ray crystallography. An IC50 value of 100 muM was determined for inhibition of DNA-PK, and this is approximately 12-fold higher than that reported previously. (C) 2001 Elsevier Science Ltd. All rights reserved.
Author(s): Martin N; Rigoreau LJM; Golding BT; Griffin RJ; Clegg W; Stockley M; Fontana G; Smith GCM
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry Letters
ISSN (electronic): 1464-3405
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