Toggle Main Menu Toggle Search

Open Access padlockePrints

Interferon plus amantadine versus interferon alone in the treatment of naive patients with chronic hepatitis C: a UK multicentre study

Lookup NU author(s): Professor Margaret Bassendine, Dr Raymond Barry


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background/Aims: The antiviral agent amantadine may have activity against the hepatitis C virus. To determine whether the combination of interferon-alpha plus amantadine was more effective than interferon monotherapy we conducted a multicentre clinical trial in untreated patients with chronic hepatitis C infection. Methods: We performed a pilot study in two centres (36 patients) to determine the number needed for a statistically significant clinical trial and then conducted a multicentre, randomized controlled clinical trial involving 14 centres and 143 patients. Results: There was no significant difference in sustained response rates in patients receiving interferon and amantadine compared to those receiving interferon alone. The on treatment response rate at 3 months was 65% on combination vs. 49% on interferon alone (P = 0.05) while the sustained response was 18 and 15%, respectively. Conclusions: Combination therapy with interferon plus amantadine does not lead to a significant increase in sustained response rates when compared to interferon monotherapy. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

Publication metadata

Author(s): Bassendine MF; Barry R; Caronia S; Mills P; Naoumov NV; Fox R; Lowes J; Hollanders D; Murray-Lyon L; Irving WL; Goldin RD; Foster GR; behalf UK Amantadine Study Grp

Publication type: Article

Publication status: Published

Journal: Journal of Hepatology

Year: 2001

Volume: 35

Issue: 4

Pages: 512-516

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641

Publisher: Elsevier B.V.


DOI: 10.1016/S0168-8278(01)00140-4


Altmetrics provided by Altmetric