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Lookup NU author(s): Hayley Whitfield, Professor Roger Griffin, Dr Ian HardcastleORCiD, Dr Alistair Henderson, Dr Jerome Meneyrol, Dr Veronique Mesguiche, Kerry Louise Sayle, Emeritus Professor Bernard Golding
SNAr displacement reactions of 6-cyclohexylmethoxy-2-fluoropurine, 6-amino-2-butylsulfonyl-4-cyclohexylmethoxypyrimidine and 2-amino-6-chloropurine with substituted anilines (e.g. the weakly nucleophilic 4-aminobenzenesulfonamide) are dramatically accelerated in the presence of trifluoroacetic acid and occur especially efficiently in 2,2,2-trifluoroethanol solvent.
Author(s): Whitfield HJ, Griffin RJ, Hardcastle IR, Henderson AP, Meneyrol J, Mesguiche V, Sayle KL, Golding BT
Publication type: Article
Publication status: Published
Journal: Chemical Communications
Year: 2003
Issue: 22
Pages: 2802-2803
Date deposited: 05/07/2010
ISSN (print): 1359-7345
ISSN (electronic): 1364-548X
URL: http://dx.doi.org/10.1039/b308948g
DOI: 10.1039/b308948g
PubMed id: 14651112
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