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A study of the prevalence of systemic sclerosis in northeast England

Lookup NU author(s): Dr Ian Forrest, Emeritus Professor Nick Europe-Finner, Dr Paul Crook


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Objectives. We aimed to obtain an estimate of the prevalence and demographics of systemic sclerosis (SSc) and its subtypes at the turn of the millennium. Methods. Case finding from multiple sources from a defined geographical area. Diagnosis confirmed by clinical examination. Results. The crude prevalence of SSc in northeast England was 8.8 (95% CI: 6.8-10.8) per 100 000. The prevalence when adjusted for the entire UK is 8.2 (95% CI: 6.2-9.8) per 100 000. The ratio of women to men was 5.2:1. The median age of patients was 57.1 yr. The ratio of limited cutaneous SSc to diffuse cutaneous SSc was 4.7:1. Limited cutaneous SSc is associated with the presence of anticentromere antibodies; diffuse cutaneous SSc is associated with anti-Scl 70 antibodies, but either antibody was found in either form of SSc. Conclusions. SSc appears to be more common in northeast England than was found in the West Midlands in 1986. This may reflect changes in the diagnostic definition of SSc.

Publication metadata

Author(s): Allcock RJ, Forrest I, Corris PA, Crook PR, Griffiths ID

Publication type: Article

Publication status: Published

Journal: Rheumatology

Year: 2004

Volume: 43

Issue: 5

Pages: 596-602

ISSN (print): 1462-0324

ISSN (electronic): 1462-0332

Publisher: British Society for Rheumatology


DOI: 10.1093/rheumatology/keh124


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