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Lookup NU author(s): Professor Raj Kalaria,
Dr John Fairlie,
Professor David Barer
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Sleep apnoea (SA) is common, especially in elderly people. In severe cases, arterial P-O2 may be lowered for a third or more in a night of sleep. To simulate the degree and duration of severe SA we exposed rats in a normobaric environmental chamber to 10% O-2 for 4 h daily for 56 days (intermittent hypoxia: 1H group) and compared them with rats continuously exposed for 8 weeks (continuous hypoxia: CH group) and control rats breathing room air (normoxic: N group). We found significant cardiopulmonary and cerebral changes. Right ventricular hypertrophy developed in 1H and to a greater extent in CH. Small peripheral lung vessels developed thicker walls (assessed by a new method), which reduced their lumen, more in CH than 1H. Coronal brain sections were immunostained for the glucose-transporter 1 (GLUT1) and the vascular endothelial growth factor (VEGF). The percentages of immunoreactivity in the frontal and temporal cortex, hippocampus, accumbens and putamen were determined by image-capture analysis. We noted GLUT1 immunoreactivity of the capillaries was similarly increased in all regions after CH but less so after 1H. However, there was a significant linear trend in GLUT1 reactivity from N to 1H to CH (R-2 = 0.73, P = 0.007) that was also confirmed by analysis of variance. The extent of VEGF-stained neurones and glial cells was significantly increased in all regions after 1H but not after CH. This suggests that the signals for angiogenesis were complete or arrested after CH. Our findings have implications for the elderly subjected to hypoxic episodes during sleep apnoea. (C) 2004 Elsevier B.V. All rights reserved.
Author(s): Kalaria RN, Spoors L, Laude EA, Emery CJ, Thwaites-Bee D, Fairlie J, Oakley AE, Barer DH, Barer GR
Publication type: Article
Publication status: Published
Journal: Respiratory Physiology & Neurobiology
ISSN (print): 1569-9048
ISSN (electronic): 1878-1519
Publisher: Elsevier BV
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