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Lookup NU author(s): Professor Vinidh Paleri,
Professor Jeffrey Pearson,
Dr David Bulmer,
Emerita Professor Janet Wilson
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OBJECTIVE. Mucins are high-molecular-weight glycoproteins present at the outer surface of mammalian cells. The objective of this study was to examine the expression of mucin (MUC) genes 3, 4, 5AC, 513, 6, and 7 in early and late laryngeal squamous cancer using the in situ hybridization technique. STUDY DESIGN: Retrospective analysis of pathological archive specimens. RESULTS: While MUC 3 and 7 are expressed in a small proportion of early cancers, MUC 5AC, 513, and 6 are not expressed in laryngeal squamous cancer. MUC 4 was expressed in 13 of the 30 patients. Ten patients and 3 patients with stage I and stage 4 disease respectively expressed MUC 4 gene (Fisher's exact, P = 0.02). MUC4-positive patients had a definite trend towards better survival (log rank test, P = 0.05). In the presence of tumor stage and comorbidity grade, Cox's proportional hazards model failed to statistically confirm the survival advantage provided by MUC 4 gene expression. CONCLUSION: There is a survival advantage for patients with advanced-stage nonmetastatic cancer when the MUC 4 gene is expressed. AIMS: To study the expression of mucin (MUC) genes 3, 4, 5AC, 513, 6, and 7 in early and advanced squamous cell cancer of the larynx; to attempt to correlate changes in gene expression with tumor stage by studying stage I and stage IV (AJCC, 1988) tumors.
Author(s): Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA
Publication type: Article
Publication status: Published
Journal: Otolaryngology - Head and Neck Surgery
ISSN (print): 0194-5998
ISSN (electronic): 1097-6817
Publisher: Mosby, Inc.