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The gene encoding the ribulose monophosphate pathway enzyme, 3-hexulose-6-phosphate synthase, from Aminomonas aminovorus C2A1 is adjacent to coding sequences that exhibit similarity to histidine biosynthesis enzymes.

Lookup NU author(s): Dr Edward Taylor


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In an attempt to understand better the organisation of genes encoding enzymes of the ribulose monophosphate pathway (RuMP), the 3-hexulose 6-phosphate synthase gene (hps) and flanking sequences were cloned from the obligate methylotroph Aminomonas aminovorus C2A1. To date only three hps containing gene clusters from methylotrophs have been characterised and these contain genes encoding other RuMP enzymes. However, hps from A. aminovorus C2A1 was shown to be adjacent to coding sequences for products with sequence similarity to histidine biosynthesis enzymes. Furthermore, none of the hps homologue containing gene clusters, from genome sequences previously analysed or analysed in this paper, were similar in organisation to that of A. aminovorus C2A1.

Publication metadata

Author(s): Taylor EJ, Smith NL, Colby J, Charnock SJ, Black GW

Publication type: Article

Publication status: Published

Journal: Antonie van Leeuwenhoek

Year: 2004

Volume: 86

Issue: 2

Pages: 167-172

ISSN (print): 0003-6072

ISSN (electronic): 1572-9699

Publisher: Springer Netherlands


DOI: 10.1023/B:ANTO.0000036130.50550.37


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