Toggle Main Menu Toggle Search

Open Access padlockePrints

Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [I-125]alpha-conotoxinMII in the striatum and thalamus

Lookup NU author(s): Dr Iwo Bohr, Professor Ian McKeith, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry, Dr Jennifer Court, Dr Margaret Piggott


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


The presence of alpha6 subunit containing nicotinic acetylcholine receptors on nigrostriatal dopaminergic neurons has been demonstrated in rodents and monkeys. [I-125]alpha-conotoxinMII is a radioligand that binds to alpha6, and also alpha3 subunits of nicotinic acetylcholine receptors (nAChRs). In the present study, we have compared the distribution of [I-125]-conotoxinMII binding in post mortem human tissue from four groups of patients: individuals with dementia with Lewy bodies displaying extra-pyramidal features (DLB + EPF), DLB without extrapyramidal features (DLB - EPF) Parkinson's disease without dementia (PD) and age-matched controls. Reduced binding was observed in the putamen and caudate in PD and both DLB groups. In DLB patients, the decline was greater in DLB + EPF compared to DLB - EPF group. The declines in nicotinic receptor binding in the striatum were in part paralleled by reductions in the striatal dopamine transporter. In the thalamus, [I-125]alpha-conotoxinMII binding was significantly reduced in the centromedian nucleus in both DLB groups, and also in the parafascicular nucleus in the DLB - EPF group. In DLB + EPF and PD patients, there was decreased binding in the ventral lateral nucleus. This study demonstrates alterations of alpha6 and/or alpha3 nAChRs binding in DLB and PD, which are likely to relate to extra-pyramidal symptoms. (C) 2004 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Bohr IJ, Ray MA, McIntosh JM, Chalon S, Guilloteau D, McKeith IG, Perry RH, Clementi F, Perry EK, Court JA, Piggott MA

Publication type: Article

Publication status: Published

Journal: Experimental Neurology

Year: 2005

Volume: 191

Issue: 2

Pages: 292-300

ISSN (print): 0014-4886

ISSN (electronic): 1090-2430

Publisher: Academic Press


DOI: 10.1016/j.expneurol.2004.10.004


Altmetrics provided by Altmetric