Browse by author
Lookup NU author(s): Dr James Pemberton, Dr Antoinette Kenny
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
OBJECTIVES The purpose of this study was to investigate whether cardiac output (CO) could be accurately computed from live three-dimensional (3-D) Doppler echocardiographic data in an acute open-chested animal preparation. BACKGROUND The accurate measurement of CO is important in both patient management and research. Current methods use invasive pulmonary artery catheters or two-dimensional (2-D) echocardiography or esophageal aortic Doppler measures, with the inherent risks and inaccuracies of these techniques. METHODS Seventeen juvenile, open-chested pigs were studied before undergoing a separate cardiopulmonary bypass procedure. Live 3-D Doppler echocardiography images of the left ventricular outflow tract and aortic valve were obtained by epicardial scanning, using a Philips Medical Systems (Andover, Massachusetts) Sonos 7500 Live 3-D Echo system with a 2.5-MHZ probe. Simultaneous CO measurements were obtained from an ultrasonic flow probe placed around the aortic root. Subsequent offline processing using custom software computed the CO from the digital 3-D Doppler DICOM data, and this was compared to the gold standard of the aortic flow probe measurements. RESULTS One hundred forty-three individual CO measurements were taken from 16 pigs, one being excluded because of severe aortic regurgitation. There was good correlation between the 3-D Doppler and flow probe methods of CO measurement (y = 1.1x - 9.82, R-2 = 0.93). CONCLUSIONS In this acute animal preparation, live 3-D Doppler echocardiographic data allowed for accurate assessment of CO as compared to the ultrasonic flow probe measurement. (C) 2005 by the American College of Cardiology Foundation.
Author(s): Pemberton J, Li XK, Karamlou T, Sandquist CA, Thiele K, Shen I, Ungerleider RM, Kenny A, Sahn DJ
Publication type: Article
Publication status: Published
Journal: Journal of the American College of Cardiology
Year: 2005
Volume: 45
Issue: 3
Pages: 433-438
ISSN (print): 0735-1097
ISSN (electronic): 1558-3597
Publisher: Elsevier Inc.
URL: http://dx.doi.org/10.1016/j.jacc.2004.10.046
DOI: 10.1016/j.jacc.2004.10.046
Altmetrics provided by Altmetric
