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The incidence and importance of bacterial contaminants of cadaveric renal perfusion fluid

Lookup NU author(s): Bryon Jaques


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Infections represent a significant risk in the postoperative transplant recipient. The perfusion fluid used to perfuse and preserve the kidneys prior to transplantation represents a potential medium in which organisms can grow. The aim of this study was to determine the incidence and clinical relevance of bacterial contamination of perfusion fluid. A total of 4 centres participated in the study and 269 perfusion fluid samples were taken for micro-biological analysis. Organisms were isolated from 38 out of 218 (17.4%) perfusion fluid samples taken prior to allograft implantation and 23 out of 51 (45%) samples taken at procurement. Low virulence organisms predominated although Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli were also isolated. Although infective complications were not seen in the allograft recipients, given the frequency with which contamination occurs and the variation in unit antibiotic protocols, we recommend the routine culturing of perfusion fluid to ensure that any potentially significant organisms are identified and treated appropriately.

Publication metadata

Author(s): Wakelin SJ, Casey J, Robertson A, Friend P, Jaques BC, Yorke H, Rigden SP, Emmanuel XFS, Pareja-Cebrian L, Forsythe JLR, Morris PJ

Publication type: Article

Publication status: Published

Journal: Transplant International

Year: 2005

Volume: 17

Issue: 11

Pages: 680-686

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1007/s00147-004-0792-6


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