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Evaluation of Daclizumab to reduce delayed graft function in non-heart-beating renal transplantation: A prospective, randomized trial

Lookup NU author(s): Christine Wilson, Muhammed Gok, Ajay Gupta, John Asher, Marsha Nicholson, David Talbot


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Daclizumab (DZB), an interleukin-2 receptor blocker, has been shown to reduce the rate of acute rejection, while non-heart-beating kidney recipients have high rates of delayed graft function that may be prolonged by high levels of calcineurin inhibitors. This study assessed whether DZB could safely replace calcineurin inhibitors in the immediate postoperative period and promote recovery from ischemic acute tubular necrosis. Patients were randomized into one of two groups: DZB induction and daily mycophenolate mofetil (MMF; 2 g) with steroids (20 mg prednisone) or standard triple therapy with tacrolimus, MMF, and prednisone. Patients in the DZB arm were converted to the control arm when either the serum creatinine dropped to < 350 mu mol/L or there was biopsy evidence of acute rejection. Over 2 years, Leicester and Newcastle non-heart-beating donor (NHBD) centers recruited 51 patients. There was one patient death in the DZB arm, during the study period, after a nonfunctioning graft was removed. A total of two (8%) grafts in the DZB arm and three (11.5%) grafts in the control arm failed to function. The overall rate of immediate function improved from around 5% (pre-2001) to 28%. There were no significant differences in the incidence of acute rejection or graft function (GFR) at 3 months. Machine-perfused kidneys in DZB-treated recipients had the highest rates of immediate function (53%, P = .015). We found that a calcineurin-sparing regime is safe and may be beneficial for recipients of machine-perfused grafts damaged by warm ischemia.

Publication metadata

Author(s): Wilson C, Brook NR, Gok MA, Gupta A, Asher JF, Nicholson ML, Talbot D

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Transplantation Proceedings: 22nd Congress of the Scandinavian Transplantation Society

Year of Conference: 2005

Pages: 1774-1775

ISSN: 0041-1345

Publisher: Elsevier Inc.


DOI: 10.1016/j.transproceed.2005.02.079

Library holdings: Search Newcastle University Library for this item

ISBN: 18732623