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Lookup NU author(s): Dr Margaret Piggott
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In order to image nAChR density in vivo in humans, [5- I-123] -iodo-3-[2(S)-2-azetidinylmethoxylpyridine ([5- I-123]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in vitro validation in human post-mortem tissue and some initial in vivo clinical studies using the ligand [5-I-123/125]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed. Copyright (c) 2007 John Wiley & Sons, Ltd.
Author(s): Pimlorr SL, Piggott M, Patterson J, Cavanagh J, Wyper DJ
Publication type: Article
Publication status: Published
Journal: Journal of Labelled Compounds and Radiopharmaceuticals
ISSN (print): 0362-4803
ISSN (electronic): 1099-1344
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