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Predisposing factors for biliary complications following liver transplantation

Lookup NU author(s): Aliu Sanni, John Asher, Dr Caroline WilsonORCiD, Hugh Wyrley-Birch, Dhakshina Vijayanand, Bryon Jaques, David Talbot, Professor Derek Manas


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Introduction. Biliary complications remain a major cause of morbidity and mortality in patients following liver transplantation. We sought to identify possible risk factors predisposing to biliary complications after OLT using duct-to-duct biliary reconstruction. Materials and Methods. We retrospectively reviewed 5 years of prospectively collected donor and recipient data between April 1999 and April 2004. We evaluated the presence of biliary complications, donor and recipient age, cold ischemia time, hepatic artery thrombosis, non-heart-beating donor (NHBD), and graft steatosis (> 30%). The results were compared with a control group of OLT patients without biliary complications. Results. Among 173 OLT recipients, biliary complications occurred in 28 patients (16.2%), of whom 12 were leaks, 15 strictures, and 1 a nonanastomotic intrahepatic stricture. The mortality following biliary complications was 11%, compared to 6% in the control group. Conclusion. Biliary complications remain a persistent problem in OLT. Analysis of risk factors identified hepatic artery thrombosis and steatosis as predisposing factors. With greater experience, NHBD livers may also prove to be at greater risk of biliary complications.

Publication metadata

Author(s): Sanni A, Asher J, Wilson C, Wyrley-Birch H, Vijayanand D, Jaques B, Talbot D, Manas D

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 4th Congress of the Andalusian Society of Organ and Tissue Transplantation (SATOT)

Year of Conference: 2006

Pages: 2677-2678

ISSN: 0041-1345

Publisher: Transplantation Proceedings: Elsevier


DOI: 10.1016/j.transproceed.2006.08.008

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