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Lookup NU author(s): Professor Peter Thelwall
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This report introduces a novel method to characterize the diffusion-time dependence of the diffusion-weighted magnetic resonance (MR) signal in biological tissues. The approach utilizes the theory of diffusion in disordered media where two parameters, the random walk dimension and the spectral dimension, describe the evolution of the average propagators obtained from q-space MR experiments. These parameters were estimated, using several schemes, on diffusion MR spectroscopy data obtained from human red blood cell ghosts and nervous tissue autopsy samples. The experiments demonstrated that water diffusion in human tissue is anomalous, where the mean-square displacements vary slower than linearly with diffusion time. These observations are consistent with a fractal microstructure for human tissues. Differences observed between healthy human nervous tissue and glioblastoma samples suggest that the proposed methodology may provide a novel, clinically useful form of diffusion MR contrast. (c) 2006 Elsevier Inc. All rights reserved.
Author(s): Ozarslan E, Basser PJ, Shepherd TM, Thelwall PE, Vemuri BC, Blackband SJ
Publication type: Article
Publication status: Published
Journal: Journal of Magnetic Resonance
ISSN (print): 1090-7807
ISSN (electronic): 1096-0856
Publisher: Academic Press
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