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Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies

Lookup NU author(s): Dr Elise Rowan, Professor Ian McKeith, Dr Brian Saxby, Professor John O'Brien, Professor David Burn, Dr Urs Mosimann, Dr Jane Newby, Sarah Daniel, Dr Jonathan Sanders


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Background: We examined attention-enhancing effects of the cholinesterase inhibitor donepezil in Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) by means of open label study. Methods: 22 DLBs and 23 PDDs were assessed over 20 weeks using the Cognitive Drug Research Computerized Attentional Tasks. We examined how much closer our patients moved towards being normal for their age by comparing them to a non-demented elderly control sample (n = 183, aged 71 - 75 years). Results: Donepezil treatment improved power of attention, continuity of attention and reaction time variability. The deficit in responses was moved towards normal by 38 and 56% for power of attention and 22 and 10% for continuity of attention in PDD and DLB, respectively. Conclusions: Improvements in attention were found with donepezil in PDD and DLB. Copyright (c) 2007 S. Karger AG, Basel. Copyright (c) 2007 S. Karger AG, Basel.

Publication metadata

Author(s): Rowan E, McKeith IG, Saxby BK, O'Brien JT, Burn D, Mosimann U, Newby J, Daniel S, Sanders J, Wesnes K

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2007

Volume: 23

Issue: 3

Pages: 161-167

Print publication date: 01/01/2007

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG


DOI: 10.1159/000098335


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Funder referenceFunder name
G0400074Medical Research Council
G0502157Medical Research Council