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Medullary microvessel degeneration in multiple system atrophy

Lookup NU author(s): Veronica Miller, Professor Raj KalariaORCiD, Arthur Oakley, Professor Rose Anne Kenny

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Abstract

Multiple system atrophy (MSA) is a rare and fatal early-onset autonomic disorder which is characterised by Parkinsonism and orthostatic hypotension (OH). The pathophysiology of MSA is not fully understood but key features include the depletion of medullary autonomic neurons and presence of glial cellular inclusions. We hypothesise that the degeneration of medullary autonomic microvessels is an additional finding in VISA. Using digital pathology we quantified basement membrane collagen (Coll IV), smooth muscle actin (alpha-actin) and endothelial glucose transporter (Glut 1) expression in medullary autonomic nuclei of 8 MSA and 8 OH cases, compared with 12 controls with no autonomic dysfunction. We found decreased Coll IV (p=0.000) and Glut 1 (p=0.000) but not cc-actin expression, in medullary autonomic nuclei of MSA, but not OH cases compared with control subjects. Medullary microvessel degeneration in MSA may be secondary to the primary neuro-glial pathogenesis of the disorder, and could accelerate its ageing-related progression. (c) 2007 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Miller VM, Kalaria RN, Hall R, Oakley AE, Kenny RA

Publication type: Article

Publication status: Published

Journal: Neurobiology of Disease

Year: 2007

Volume: 26

Issue: 3

Pages: 615-622

ISSN (print): 0969-9961

ISSN (electronic): 1095-953X

Publisher: Academic Press

URL: http://dx.doi.org/10.1016/j.nbd.2007.03.005

DOI: 10.1016/j.nbd.2007.03.005

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